Assessment of Radiation Induced Damage of Mouse Brain Using 18F-2-Deoxy-D-Glucose and 99mTc-Hexamethylpropylene Amine Oxine

The most severe radiation-induced brain damage is brain necrosis. Clinically, it is difficult to differentiate between brain necrosis and recurrent brain tumor1. Radiation brain necrosis is a terminal stage of the brain damage. However, it is not well known the mechanisms underlying the process that produce the brain necrosis after irradiation: i.e. how glucose metabolism and blood flow distribution change after irradiation. We studied the uptake of 18F-2-deoxy-D-glucose (FDG) and 99mTc-hexamethylpropylene amine oxine (HMPAO) in the irradiated brain of the mouse regarding glucose and blood flow distribution, respectively. This study is a feasible for positron emission tomography.