Copper Subtype of Alzheimer Disease: A Genetic Study of ATP7B Frequency

Objectives: Meta-analyses show that nonbound ceruloplasmin copper (Non-Cp-Cu, also known as “free” or labile copper) in serum is higher in patients with Alzheimer disease (AD). It was demonstrated that ATP7B gene associates with AD, and being carriers of some ATP7B variants accounted for a large proportion of serum Non-Cp-Cu levels, …