Intermediate CAG repeats in Huntington´s disease. A longitudinal analysis of the European Huntington´s Disease Network REGISTRY Cohort (S25.003)

Background: There is still controversy about the clinical consequences of intermediate alleles (IAs) in Huntington´s disease (HD). We report longitudinal data to establish the clinical manifestations of intermediate allele (IAs) carriers, for a prospective, international, European Huntington Disease database registry (EHDN). Methods: We assessed a cohort of participants at risk with 60 yo). IAs and controls were compared for sociodemographic, environmental, and outcome measures. We used linear regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12190 participants, 657 (5ˑ38[percnt]) participants with Disclosure: Dr. Cubo Delgado has received personal compensation for activities with Abbott and UCB Pharma. Dr. Ramos-Arroyo has nothing to disclose. Dr. Martinez-Horta has nothing to disclose. Dr. Martinez-Descalls has nothing to disclose. Dr. Gil-Polo has nothing to disclose.