Synthesis of 4-[4-(N, N-dimethylsulfamoyl)piperazin-1-yl]-quinolines derivatives as sorbitol dehydrogenase potential inhibitors

Synthesis of various quinolines, substituted in position 4 by [4-(N,N-dimethylsulfamoyl)piperazin-1-yl] group and in position 2 by different groups such as hydrogen, methyl, hydroxymethyl, formyl or carboxyl is described.Besides, we have synthesized derivatives of 8-hydroxyquinoline.