The Histologic effects of the Uyghur medicine Xipayi KuiJiean on ulcerative colitis in rats

Objective: To create a rat model of ulcerative colitis (UC) and to observe and describe histopathological effects of the Uyghur medicine, Xipayi KuiJiean (XKJ) on this model. Methods: A rat model of ulcerative colitis was established by applying 2.4-dinitrochlorobenze (DNCB) composite acid to rats. Two concurrent groups were set up: an intervention group using the Uygur medicine, Xipayi Kuijiean, and a control group using normal saline. The intervention group was further divided according to medicine dosage: large, medium and small dose levels, respectively. Using the colon tissue histopathology detection index, we observed histopathological changes and analyzed the effects of XKJ on UC. Results: Within the intervention group, we observed clear histopathologic effects from large and medium doses of XKJ on the intestinal mucosa of rats, including: minimal interstitial inflammatory cell infiltration and reduced edema compared to controls. Similar effects were also seen with small doses, but signs of tissue repair were slower to become evident. There were no significant statistical differences differences between the observed effects of large and medium doses of XKJ. However, the differences between the combined large-medium dose observations and those of small doses were statistically significant. Conclusion: A histopathological model of ulcerative colitis using DNCB composite acid method on rats was successful. The Uyghur medicine, Xipayi KuiJiean, can reduce histologic signs of damage to the tissues of these UC model rats, demonstrating a therapeutic effect. These observations suggest that the Uyghur medicine, Xipayi KuiJiean, may be effective in the treatment of UC.