Experimental studies on haematogenous osteomyelitis due to Staphylococcus hyicus in mice

: 10(7) colony forming units of 18 different strains of Staphylococcus hyicus were intravenously administered into mice. Five mice as a group received each strain of S. hyicus. At 14 days after inoculation, 11 out of 18 strains were found in the bone marrow. Out of these 11 strains, SMUH 10 and SMUH 18 caused remarkable inflammation which was characterized by roentgenographical change. A number of these organisms were detected in the bone marrow until 28 and 42 days after the injection, suggesting specific lodgement of the strain in mouse bone marrow. X-rays of the upper and lower extremities taken 14 days after inoculation showed multiple small radiolucent areas surrounded by small rims representing osteosclerosis. However, these changes did not show any aggravation during 70 days after inoculation suggesting tendency of improvement.