The 2-phase case-control design: an efficient way to use expert-time.

The paper presents an optimized way to use expert exposure assessment in a subsample of cases and controls, chosen to maximize its information content in the context of a 2-phase lung cancer caseâ€＂control. This study showed doseâ€＂response relationships with exposure to diesel motor exhaust, asbestos, PAH and crystalline silica.