P260 Potential Impact of the 2015 NICE Consultation Guideline for Tuberculosis on the number of children assessed and treated for TB infection and disease in the UK: Abstract P260 Table 1

Background NICE Tuberculosis (TB) guideline 2015 recommends all children, regardless of BCG status, with Mantoux ≥5 mm induration receive treatment for latent TB once active TB has been excluded. The 2011 version defines a positive Mantoux as ≥6 mm (no prior BCG) and ≥15 mm (prior BCG). NICE 2011 recommends screening of household contacts of all cases of TB compared with the 2015 guideline which recommends screening of contacts of pulmonary TB only. Objectives To establish the impact of the change in NICE recommendations on the number of children assessed and treated for latent TB infection (LTBI) or TB disease in our department. Methods We performed a retrospective analysis of all children. Results 445 patients were referred, 75 with symptoms, 138 new entrants, 63 non-pulmonary contacts and 169 pulmonary contacts. Of those with symptoms, 5 had positive Mantoux (NICE 2011) compared with 18 (NICE 2015). In this group 0/75 were treated for LTBI and 7/75 for TB disease. Results of patients referred for contact tracing/new entrant screening are shown in Table 1. Two contacts with LTBI and 1 with TB disease (all IGRA positive) would have been missed by the 2011 guideline but identified in 2015. Following NICE 2015 63 non-pulmonary contacts would not have been seen. None of these had LTBI or TB disease. Of the remaining 307 contacts/new entrants 47(15%) had a positive Mantoux of whom 11(4%) had LTBI and 4(1%) TB disease. Conclusion 37% more children will be investigated and treated for TB infection/disease under the new NICE TB guideline. In a 12 month period in our clinic this represents 33 additional children with 1 extra case of TB disease and 2 cases of LTBI identified.