1,3,4-oxadiazole derivative containing glucosamine molecules and preparation method and application thereof

The invention provides a 1,3,4-oxadiazole derivative containing glucosamine molecules. R in the molecular formula is selected from -CH3, -C2H5, -C4H11, -C6H5, -C5H4N, 4-OHC6H4-, 3-CH3C6H4, 4-CH3C6H4-, 3-CH3OC6H4-, 2-NO2C6H4-, 4-NO2C6H4-, 2-FC6H4-, 4-FC6H4-, 2-ClC6H4-, 3-ClC6H4-, 3-BrC6H4-, 4-IC6H4-, 4-N (CH3)2C6H4-, -C4H3S, and -C4H3O. The invention further discloses a synthesis method and application of the 1,3,4-oxadiazole derivative containing the glucosamine molecules. The adopted synthesis method has the advantages of being easy and convenient to implement, rapid, high in applicability, efficient and the like. An adopted cyclization reagent has the advantages of being low in price, low in toxicity and the like. The glucosamine molecules are introduced into the 1,3,4-oxadiazole molecules, and the synthesized target compound has the strong inhibitory activity for acetylcholin esterase, thereby having the wide application prospect in the aspect of preparation of anticholinesterase medicine.