Separation of Cyclopropane Derivatives with Multichiral Centers by Gas Chromatography on Modified β-Cyclodextrin Stationary Phase

A new pyridine heterocyclic β-cyclodextrin derivative, heptakis[2,6-di-O-pentyl-3-O-(2-chloro-5-pyridyl)methyl]-β-CD, was synthesized and explored as chiral stationary phase in capillary gas chromatographic separation. Cyclopropane derivatives with two chiral centers including four configurational isomers or three chiral centers including eight configurational isomers were well separated, which indicated the new pyridyl β-CD derivative possessing excellent chiral selectivity for separation of complex compounds including multichiral centers.