Effect of 2-Deoxyglucose on Insulin Secretion in the Rabbit

The intravenous injection of 2-deoxyglucose (2-DG), 0.5 g/kg, in the portal vein of rabbits was not followed by insulin secretion, in spite of the intense hyperglycemia produced by this sugar. Dihydroergotamine (DHE), when administered in amounts of 0.3 mg/kg, prevented the 2-DG-induced hyperglycemia; and in such conditions, a late rise in plasma insulin levels was detected When the rabbits were pretreated with DHE, the administration of 2-DG did not block the insulin release induced by glucose, glucagon or tolbutamide.The significance of these findings is discussed.