Histopathological effect of powder detergent on the livers of laboratory mice Mus musculus

The powder detergents are one of the chemical substances using in daily life. Like other chemical substances, detergents have detrimental effects on the human body. Therefore, the impact of powder detergent was tested in this study. The pathological effects of powder detergent on the liver were investigated by ingesting 80 mice Mus musculus strain with detergent solution. Mice were divided into (8) groups. The control group was ingested vegetables (celery) only, while the groups were ingested celery which soaked in the aqueous solution of powder detergent with various concentrations at the different times (1.5g/Kg for 15min, 3g/Kg for 15min, 4.5g/Kg for 15min, 1.5g/Kg for 30min, 3g/Kg for 30min, 4.5g/Kg for 30min, 1.5 g/Kg for 1-2min). The livers of the mice in ingested groups showed marked histopathological changes included cloudy swelling and infiltration of mononuclear inflammatory cells. Additionally, vascular congestion and hepatocellular necrosis as indicated by karyolysis with narrowing of the sinusoids. Considerable nuclear pyknosis, karyorrhexis, marked hydropic degeneration associated with Kupffer cell hyperplasia. Extending of injuries increased with rising the concentration and duration of exposure to the detergents. The results of the study emphasize the health hazards for exposure to the detergent, so a reasonable approach to tackle this issue could be by proper handling and disposal the detergents during daily life using.