Smartphone data during the COVID-19 pandemic can quantify behavioral changes in people with ALS.
2020
Introduction/aims Passive data from smartphone sensors may be useful for healthcare research. Our aim was to use the COVID-19 pandemic as positive control to assess the ability to quantify behavioral changes in people with amyotrophic lateral sclerosis (ALS) from smartphone data. Methods Eight participants used the Beiwe smartphone application which passively measured their location during the COVID-19 outbreak. We used interrupted time series to quantify the effect of the US state of emergency declaration on daily home time and daily distance traveled. Results After the state of emergency declaration, median daily home time increased from 19.4 hours (IQR: 15.4-22.0) to 23.7 hours (IQR: 22.2-24.0) and median distance traveled decreased from 42 km (IQR: 13-83) to 3.7 km (IQR: 1.5-10.3). The participant with the lowest functional ability changed behavior earlier. This participant stayed at home more and traveled less than the participant with highest functional ability, both before and after the state of emergency. Discussion We provide evidence that smartphone-based digital phenotyping can quantify the behavior of people with ALS. Even though participants spent large amounts of time at home at baseline, the COVID-19 state of emergency declaration reduced their mobility further. Given participants' high daily home time, it is possible that their exposure to COVID-19 could be lower than that of the general population.
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