Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities

Prosopis africana , Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana . Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis , M. tuberculosis . The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.