Comparison of Varying Bolus Doses of Oxytocin in Patients Undergoing Caesarean Spinal Delivery

caesarean delivery avoiding side effects.Study design and setting: A study was conducted at Rawal General and Dental Hospital, from 10th Oct, 2018 to 27thMay, 2019.Methodology: Patients undergoing elective cesarean spinal delivery were randomly divided by computer generatednumbers(n=155) into 5 groups A, B, C, D and E receiving 0.5, 1, 3, 5 and 10 units of injection oxytocin as bolus respectivelyafter delivery of baby. Uterine contraction was assessed by gynecologist by manual palpation of uterus on a linear scale.Value of 8 was considered adequate and 8 inadequate uterine tone respectively. Heart rate, non-invasive blood pressureand oxygen saturation were noted before and after oxytocin bolus. All patients received oxytocin infusion. The primaryoutcome measure was the assessment of uterine tone at 2 minute of oxytocin bolus. The secondary outcome variablesincluded shortness of breath, chest discomfort, top-up bolus administered, hemodynamic variables, epigastric discomfortand oxytocin related effects (tachycardia, epigastric discomfort and hypotension).Results: The use of 5 units oxytocin (group-D) showed most optimal uterine contractions, 61.3% in comparison to commonlyused 10 units bolus dose (group-E) 48.4% with minimal side effects like, less tachycardia(12.9% versus 72.9%) andhypotension (12.9% versus 32.3%), no top-up bolus dose was required in 54.8% cases and no complain of epigastricdiscomfort was observed.Conclusion: Low doses of oxytocin are effective in terms of uterine contraction with minimal side effects.