One kind (s) -2- resolution methods arylpropionic acid class of non-steroidal anti-inflammatory drugs

The present invention relates to a method for resolving chiral drugs, particularly, to a (S) -2- aryl propionic acids resolution methods of nonsteroidal anti-inflammatory drug. Main resolving agents used in the method of resolving agent is optically pure cluster from a variety of chiral resolving agent consisting of auxiliary resolving agent is an organic or inorganic base, comprises the following steps of: (RS) -2- aryl propionic acid or its salt with the resolving agent after the main proportion mixing, auxiliary co resolving agent dissolved in a solvent, wherein an optically isolated to give pure 2-aryl-propionic acid complex salt; mother liquor obtained after high temperature rac can repeat the resolution process; purified double salt after taking, with a base to its decomposition analysis method, and extracted with an organic solvent separation process or pH adjustment, the title compound separated with the resolving agent to obtain a high yield, high quality optical pure (S) -2- arylpropionic acids or salts thereof. Resolving agent used in the present invention is low cost, less consumption, non-toxic solvent, split high efficiency, suitable for industrial production.