A symmetrical and biodegradable cationic lipid. Synthesis and application for efficient gene transfection

Satoshi Obika,Wei Yu,Atsuko Shimoyama,Takeshi Uneda,Kazuyuki Miyashita,Takefumi Doi,Takeshi Imanishi

A symmetrical and biodegradable cationic lipid. Synthesis and application for efficient gene transfection

1997

Satoshi Obika
Wei Yu
Atsuko Shimoyama
Takeshi Uneda
Kazuyuki Miyashita
Takefumi Doi
Takeshi Imanishi

Abstract A novel cationic lipid with a symmetrical and biodegradable structure was synthesized, and the transfection efficiency and the cytotoxicity of the cationic liposomes composed of the cationic lipid and dioleoylphosphatidylethanolamine (DOPE) were studied.

Keywords:

Liposome
Phospholipid
Cationic polymerization
Phosphatidylethanolamine
Cationic liposome
Transfection
Lipid metabolism
Biochemistry
Organic chemistry
Genetic enhancement
Chemistry
Cytotoxicity

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