Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.

Mounir Andaloussi,Martin Lindh,Christofer Björkelid,Surisetti Suresh,Anna Wieckowska,Harini Iyer,Anders Karlén,Mats Larhed

Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.

2011

Mounir Andaloussi
Martin Lindh
Christofer Björkelid
Surisetti Suresh
Anna Wieckowska
Harini Iyer
Anders Karlén
Mats Larhed

Two series of FR900098/fosmidomycin analogs were synthesized and evaluated for MtDXR inhibition and Mycobacterium tuberculosis whole-cell activity. The design rationale of these compounds involved ...

Keywords:

Mycobacterium tuberculosis
Fosmidomycin
Enzyme
Hydroxamic acid
Tuberculosis
Biochemistry
Chemistry
Enzyme inhibitor
Stereochemistry

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