Multicompartmental Computer Analysis of 111In-Tropolone Labelled Blood Platelet Kinetic Data in Normal Humans

Scintillation camera imaging of the in vivo distribution of platelets labelled with 111In has become a routine investigative procedure. Computer assisted image analysis further enables one to determine the radioactivity in an organ and to quantify the percentage of whole body radioactivity in that organ1. The limitation of imaging is that, within an organ, there is no distinction between platelets that are functional from those that have been injured during collection, or have been sequestrated1,2. Since imaging cannot distinguish between these components of organ radioactivity, we used compartmental