Diagnosis and treatment for acrallentiginous

The invention belongs to the field of medical treatment, and relates to a diagnosis and/or treatmentpreparation for acrallentiginous and application of the preparation. The invention provides a gene marker for the auxiliary diagnosis and/or treatment of the acrallentiginous. The gene marker comprises a gene CDK4, CCND1 and P16INK4a. The preparation is based on certain relation between the acrallentiginous and the copy number variation of CDK4 pathway relevant genes, takes a CDK4 pathwayinhibitor as a novel treatment strategy for the acrallentiginous, and provides a guidance basis for the individualized drug administration of the acrallentiginous.