Nitrile Oxide Cycloaddition of Non-Activated Alkynes: A Novel Approach to the Synthesis of Neuroactive Isoxazoles.

Paolo Pevarello,Raffaella Amici,Maristella Colombo,Mario Varasi

Nitrile Oxide Cycloaddition of Non-Activated Alkynes: A Novel Approach to the Synthesis of Neuroactive Isoxazoles.

2010

Paolo Pevarello
Raffaella Amici
Maristella Colombo
Mario Varasi

A general method for the unprecedented 1,3-dipolar cycloaddition of bromonitrile oxide to disubstituted non-activated alkynes provides a useful alternative route to the neuropharmacological tools AMPA and 4-methylhomoibotenic acid.

Keywords:

Oxide
Nitrile
Cycloaddition
Organic chemistry
Chemistry

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