A Case of Leukocytoclastic Vasculitis Following SARS-CoV-2 Vaccination

Abstract Background While vaccination against coronavirus SARS-CoV-2 has been proven generally safe, rare but potentially serious adverse reactions do occur. Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis that has been associated with other immunizations, but, to our knowledge, has not been previously reported in association with vaccines directed against SARS-CoV-2. Case Report We report the case of a 22-year-old man with no known past medical history who presented to the Emergency Department (ED) with two days of migratory arthritis in his ankles and palpable purpura on his bilateral lower extremities, occurring ten days after receiving the Johnson & Johnson SARS-CoV-2 vaccine. The patient's clinical presentation was suggestive of leukocytoclastic vasculitis, and this diagnosis was confirmed on skin biopsy.