슬관절 전치환술후 C - 반응성 단백질의 변화양상에 관한 연구

The early detection of deep infection is very important for the total knee replacement because post-TKR infection affords disastrous results. The C-reactive protein is widely used as a marker for detection of postoperative infection. But there were few papers ahout C-reactive protein levels after total joint replacement, especially after total knee replacement respect to its value. We analysed the change of C-reactive protein value after total knee replacement in osteoarthritis and rheumatoid arthritis, peiformed from April, 1993 to Dec. 1995. The results are as f'ollows: 1. In OA, postoiperative maximum C-reactive protein values were reached in 3 day at'ter surgeq. The C- reactive protein values werc decreased fastly and then, the values were consistently normalized nearly 2 weeks after the operation. 2. The C-reactive protein levels in RA were higher than in OA before the operation. The values were restored to pre-operative level in nearly 1 week after operation. 3. The peak level of C-reactive protein was usually reached on the third day after the operation. The incidence of high value in C-reactive protein, above 10 mg/dl, was more frequent in OA than in RA. 4. The bone cement gives no effect on C-reactive protein values in OA and RA. We think that this results will be helpful for early detection of infection after total knee replacement.