Epstein-Barr Virus-Induced 3 (EBI3) is Expressed Only in a Subset of EBV-Positive Extra Nodal NK/T Cell Lymphoma

Epstein-Barr virus-induced 3 (EBI3) encoded by the EBI3 gene was identified by the induction of its expression in B lymphocytes by EBV infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28-kDa protein to form interleukin 27 (IL-27). Given this function, we hypothesized that EBI3 could serve as …