Clinical analysis of myocardial enzymes in laparoscopic surgical patients during carbon dioxide pneumoperitoneum

Objective To explore the effect of myocardial enzymes on laparoscopic surgical patients during carbon dioxide(CO2) pneumoperitoneum,reduce and prevent the complications,therefore,improve the safety of laparoscopic surgery. Methods Three hundred and sixty one patients undergoing laparoscopic surgical during May 2009 and October 2012 were taken the related laboratory tests. The patients received laparoscopic surgery under CO2 pneumoperitoneum during surgery.LDH,CK,CK-MB,TnT and BNP were recorded at four time points of before insufflations(T0),CO2 insufflation for 15 min(T1),40 min(T2) and after surgery for 48 hour(T3).Meanwhile,the data were analyzed and preventive measures were taken. Results LDH(88.90±33.40)U/L,CK(34.50±16.10)U/L,CKMB(0.06±0.01)ng/ml,TnT(18.40±3.40)pg/mL and BNP(128.60±45.60)U/L are in the normal range at T0. There were no significant difference between T0 and T1 in LDH,CK,CK-MB,TnT and BNP(P 0.05). There were significant difference between T1 and T2 in LDH(123.00±33.60)U/L,CK(120.00±17.80)U/L and CK-MB(172.00±38.80)U/L(P 0.05).However,all the data returned to normal at T3(P 0.05). Conclusion It can lead to temporary elevated cardiac enzymes in laparoscopic surgery during CO2 pneumoperitoneum,but return to normal within two days.Laparoscopic surgery had no significant effecst on myocardial enzymes,is a safe and effective surgical method.