Development of optimised synthesis of 4-amino-N-(4-carbamoylphenyl)benzamide for industrial application

An efficient two-step synthetic route for preparation of the important Pigment Yellow 181 intermediate 4-amino-N-(4-carbamoylphenyl)benzamide is described. The synthetic pathway reflects requirements that are important for industrial applications. Optimisation of the reaction steps was performed to improve yields and procedures. The overall yield was higher than 78 %.