Studies concerning the relationship between essential elements content and myorelaxant effect of three vegetal selective fractions

The aim of this study was to obtain selective fractions with high-content in magnesium, calcium, zinc and chromium from Lavandula angustifolia Mill., Melissa officinalis L. si Achillea millefolium L. and to assess their myorelaxant effect in vivo. From 100g vegetal material of each species, there were obtained: 9,5g selective fraction from Lavandulae flos containing 4253,8 ppm magnesium, 2136,5 ppm calcium, 106,27 ppm zinc and 7,08 ppm chromium; 10g selective fraction from Melissae folium containing 4813,0 ppm magnesium, 5783,3 ppm calcium, 130,74 ppm zinc and 5,64 ppm chromium and 7g selective fraction from Millefolii flos containing 8331,1 ppm magnesium, 2318,0 ppm calcium, 183,4 ppm zinc and 6,08 ppm chromium. The pharmacological assay using grip strength test revealed that all selective fractions exhibit obvious sedative (myorelaxant) effect, although a correlation between the amount of magnesium, calcium, zinc and chromium administrated to animals and myorelaxant activity cannot be established.