FerriIridium: A Lysosome‐Targeting Iron(III)‐Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells

Reported is the Fe(III) -activated lysosome-targeting prodrug FerriIridium for gastric cancer theranostics. It contains a meta-imino catechol group that can selectively bond to, and be oxidized by, free Fe(III) inside the cell. Subsequent oxidative rearrangement releases Fe(II) and hydrolyses the amine bond under acidic conditions, forming an aminobipyridyl Ir complex and 2-hydroxybenzoquinone. Thus, Fe(II) catalyzes the Fenton reaction, transforming hydrogen peroxide into hydroxyl radicals, the benzoquinone compounds interfere with the respiratory chain, and conversion of the prodrug into the Ir complex leads to an increase in phosphorescence and toxicity. These properties, combined with the high Fe(III) content and acidity of cancer cells, make FerriIridium a selective and efficient theranostic agent (IC50 =9.22 mum for AGS cells vs. >200 mum for LO2 cells). FerriIridium is the first metal-based compound that has been developed for chemotherapy using Fe(III) to enhance both selectivity and potency.