Genetic variability in the promoter region of TNF-α gene in the reservoir of Junin virus, Calomys musculinus (Rodentia, Cricetidae)

In this study, we assessed the genetic variability of the promoter region of TNF-α gene in three natural populations of the cricetid rodent Calomys musculinus. This species is the natural reservoir of Junin virus, the etiological agent of Argentine Hemorrhagic fever. We found different levels of variability and varying signatures of natural selection in populations with different epidemiological histories.