New Indolic Non-Peptidic HIV Protease Inhibitors from (S)-Glycidol: Synthesis and Preliminary Biological Activity.

A series of non-peptidic HIV protease inhibitors were synthesized starting from the same optically active precursor, (S)-glycidol. The substrate was easily converted into different indolic sulfonamides or amines by regioselective reactions. The preliminary inhibitory activity was evaluated.