61 EFFECT OF COLD ISCHEMIA ON THE FUNCTION AND SURVIVAL OF RENAL ALLOGRAFTS.

Use of kidneys from extended criteria donors (ECD) and donors after cardiac death (DCD) has increased due to scarcity of standard criteria donor (SCD) kidneys. DCD kidneys due to preprocurement ischemia and ECD kidneys due to marginal quality are likely to suffer from delayed graft function (DGF) and early graft loss. Any prolonged cold ischemia time (CIT) is likely to add to the injury, although this has not been specifically addressed. We examined the relationship between CIT and the function and survival of these kidneys and compared to SCD kidneys using the 2004 UNOS data set. In 2000, 9,469 (87%) kidneys were SCD, 165 (2%) were DCD, and 1,191(11%) were ECD. The donor age were 31 ± 14 years and 34 ± 17 years for SCD and DCD and higher at 60 ± 6 years for ECD kidneys (mean ± SD). CIT were similar: 18.6 ± 8.3 hours, 19.0 ± 8.4 hours, and 18.7 ± 8.3 hours. The HLA mismatches were not different, but the recipient age was higher for ECD (52 ± 13 years) than for DCD (48 ± 13 years) or SCD kidneys (43 ± 14 years) ( p