Expression of components of metabolic syndrome and related diseases in patients with colorectal tumor at different stages

Objective Through analyzing the expression of components of metabolic syn drome (MS) and related diseases in patients with colorectal tumor at different stages to assess their relationship with the development of colorectal tumor.Methods From January 2003 to October 2010,hospitalized patients who received endoscopic or surgical resection of colorectal tumor were set as research group.The research group was divided into non-progressive tumor group and progressive tumor group.Patients underwent colonoscopy examination and excluded of colorectal tumor and inflammatory bowel diseases (IBD) were set as control group.The prevalence of MS components and related diseases (obesity,hypertension,hyperglycemia,dyslipidemia,hyperuricemia and nonalcoholic fatty liver disease) in patients of each group were compared.The relationship between MS components,related diseases and different stages of colorectal tumor was analyzed.Chi-square test was performed in statistics analysis.Results A total of 405 patients were enrolled in research group.The male to female ratio was 1.66 ∶ 1.Among them there were 132 cases in non-progressive tumor group and 273 cases in progressive tumor group (including 36 carcinomas in situ or invasive carcinomas).There were 76 patients in control group; the male to female ratio was 1.11 ∶ 1.The prevalence of hypertension in research group was significantly higher than that of control group [48.6％ (197/405) vs 32.9 ％ (25/76),x2 =6.3851,P=0.0115].The prevalence of hypertension in progressive tumor group 53.8％ (147/273) was 2significantly higher than that of non-progressive tumor group (37.9 ％,50/132,x =9.0809,P =0.0026)and control group (x2=10.4406,P=0.0012).And the prevalence of hyperglycemia was also significantly higher than that of non-progressive tumor group [22.3％(61/273) vs 13.6％(18/132),x2 =4.2971,P=0.0382] and control group (11.8％,9/76,x2 =4.0894,P=0.0432).In research group,the percentage of cases with at least one MS component was 76.5％ (310/405),which was higher than that of control group (63.2％,48/76,x2 =6.0240,P=0.0141).The percentage of cases with at least one MS component in progressive tumor group was 81.0 ％ (221/273),which was higher than that of non-progressive group (67.4％,89/132,x2 =9.0695,P=0.0026).The increasing of MS component was associated with the increasing percentage of progressive tumor (x 2 =9.1508,P=0.0274).The percentage of colorectal cancer was 10.6 ％ (33/310) in patients with colorectal tumor and MS components,which was higher than that of patients without MS components (3.2％,3/95,x 2 =5.0334,P=0.0249).Conclusion Concomitant MS components could be associated with the development of colorectal tumor. Key words: Metabolic syndrome X;  Colorectal neoplasms;  Prevalence;  Epidemiologic studies