Cu(II) complex of a new isoindole derivative: structure, catecholase like activity, antimicrobial properties and bio-molecular interactions

An isoindole based Cu(II) complex, [Cu(PICPH)Cl2], was synthesized in situ by reacting copper(II) chloride with a pyridine derived ligand, PICPH. The complex was characterized by spectroscopic techniques while its structure was confirmed by single crystal X-ray diffraction analysis. The complex has a trigonal bipyramid geometry containing both five- and seven-member chelate rings. It shows catecholase-like activity. Interaction of the complex with a bio-relevant antipyrine derivative (ANNAP) was studied using fluorescence spectroscopy. DFT studies unfold the energetics associated with PICPH, [Cu(PICPH)Cl2] and the adduct between [Cu(PICPH)Cl2] and ANNAP. Antimicrobial activities of the compounds were also studied.