Intracellular distribution of newly formed hepatocyte RNA in the 1st hours following partial hepatectomy

: Two periods in the activity of cell are distinguished during the first three hours after partial hepatectomy. The first period (about 0.5 h) is characterized by the activation of RNA synthesis in all the compartments of the cell, including mitochondria, and by approach of the latter to the nucleus, which is probably induced by the demand of a great quantity of energy for both the present and subsequent intranuclear synthesis. These data have permitted referring the response of hepatocytes in the first period to nonspecific ones. The second period (0.5-3 h) is distinguished by the differentiated response of hepatocytes to the proliferative stimulus.