Concepts and Rationale for Using Predictive Algorithms for Hematopoietic Progenitor Cell Apheresis Collection

Predictive algorithms for hematopoietic progenitor cell (HPC) collection are useful tools to increase efficiency of the collection, of the workflow in both the collection center and processing laboratory, and to facilitate concurrent quality assurance. Once established within a center, their use can also decrease costs by decreasing the number of days of growth factor used for mobilization and by decreasing the number of collection days or length of a collection, leading to a decrease in number of blood products transfused during collection since platelet loss can be minimized. Many approaches to predictive algorithms have been tried, and this chapter presents an overview of their history as well as a useful general strategy for current practice.