NONMEM: AN ALTERNATIVE TO TRADITIONAL PHARMACOKINETIC STUDIES IN PEDIATRIC POPULATIONS

Traditional pharmacokinetic studies provide valuable information for optimizing the clinical use of pharmacologic agents. These studies generally require careful and extensive sampling of blood from subjects to determine pharmacokinetic parameters, making them less useful and less feasible in pediatric practice. As a result, data from adult patients or volunteers are often erroneously extrapolated for pediatric use.