A sensitive liquid chromatography–tandem mass spectrometry method for the quantification of mometasone furoate in human plasma
2005
Abstract A robust, rapid, selective and sensitive liquid chromatography-negative atmospheric pressure chemical ionization (LC–(APCI − )–MS–MS) method has been developed for the quantification of mometasone furoate (MF) in human plasma utilizing a solid-phase extraction clean-up step and 13 C-fluticasone propionate as internal standard. The intra- and inter-day coefficients of variation were ≤15% and the lower limit of quantification (LLOQ) was 15 pg/ml. This method is ideally suited for pharmacokinetic investigations of low MF levels following inhalation of MF.
Keywords:
- Solid phase extraction
- Detection limit
- Mometasone furoate
- Liquid chromatography–mass spectrometry
- Analytical chemistry
- Atmospheric-pressure chemical ionization
- Tandem mass spectrometry
- High-performance liquid chromatography
- Chromatography
- Coefficient of variation
- Chemistry
- Propionate
- lower limit
- human plasma
- Pharmacokinetics
- Correction
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