MAGNETIC BEHAVIOR AND ANTIBACTERIAL ACTIVITY OF IRON (III) COMPLEXES

ABSTRACT The preparation, magnetic characterization and antimicrobial properties of the complexes [Fe 3 O(CH 3 COO) 6 (CH 3 COOH)(H 2 O)]Cl(MeImid)·(H 2 O) (1) and [Fe 4 O 2 (CH 3 COO) 7 O 2 (BPA) 2 (H 2 O)]· Cl·1.25(CH 3 CH 2 OH)(H 2 O) (2), where MeImid is 2-methyl-imidazolium and BPA is 2,2´-bipyridine, are described.The variable temperature susceptibilities of these complexes were investigated in the temperature range 2-300K. The data have been modeled on the assumption of “butterfly” arranged for (2) and equilateral triangle of ferric ions for (1).The antimicrobial activities of these complexes have been screened in vitro against different bacterial strains. The complexes (1) and (2) display activity over Gram negative bacteria and these compounds not present activity over Gram positive strains. These complexes have bacteriostatic effect over bacterial target. The toxicity analyses of iron complexes showed these have cytotoxicity effect to values around the MIC on human cell.Keyword: iron complexes, magnetism, antibacterial activities.e-mail: aatria@ciq.uchile.cl