Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6

Hui-li Li,Yuanyuan Wang,Zhangqing Zhou,Fang Tian,Huanhuan Yang,Juzhen Yan

Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6

2019

Hui-li Li
Yuanyuan Wang
Zhangqing Zhou
Fang Tian
Huanhuan Yang
Juzhen Yan

AbstractObjective: To investigate effects of combination use of leflunomide and benazepril on diabetic nephropathy (DN) both in vivo and in vitro.Methods: The streptozotocin (STZ) induced Sprague-D...

Keywords:

Diabetes mellitus
Diabetic nephropathy
TRPC6
Benazepril
Transforming growth factor
Pharmacology
Internal medicine
Medicine
Leflunomide
Endocrinology
Apoptosis
NF-κB
In vivo
Streptozotocin

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