Comparative study of sex hormone levels in patients with Alzheimer's disease

Objective To study the change and clinical significance of serum sex hormone levels in patients with Alzheimer's disease(AD). Methods The 1: 1 case-control study, male AD group in 25 cases, control group in 25 cases, female AD group in 25 cases, 25 cases in the control group.The serum sex hormone levels were measured by chemiluminescence immunoassay in the two groups, and the data were analyzed. Results There was statistically significant difference in estradiol level between female patients and the control group[(40.820±23.249)pmol/L vs.(153.700±113.900)pmol/L, t=4.85, P 0.05). The promoting follicle stimulating hormone and luteinizing hormone, progesterone, prolactin levels between the male group and female group had no statistically significant differences (all P>0.05). In patients with simple intelligent screening scale(Mini-Mental State Examination, MMSE), the score was significantly correlated with the level of estradiol (r=-0.281, P<0.05). Conclusion The level of women's estrogen decline is related to factor in the pathogenesis of AD, estradiol, testosterone levels of male decline is related to factor in the pathogenesis of AD.Estradiol level is low, the severity of the disease more and more heavy. Key words: Alzheimer's disease; Sex hormone-binding globulin; Case-control study