Short communication Significance of chymase inhibition for prevention of adhesion formation

To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80F0.20; chymase inhibitor, 1.60F0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation. D 2003 Elsevier B.V. All rights reserved.