Вегетативный дисбаланс при острой коронарной патологии

Purpose. To study the relationship of the autonomic nervous system in acute coronary syndrome with structural-functional state of the heart and blood biochemical parameters.Materials and methods. The vegetative status of 102 patients with acute coronary syndrome was estimated according to the data of rhythmic cardiogram. Also the following indicators were analysed: data of 24 hour ECG monitoring, ultrasonic data of structural and functional heart rates, fibrinogen, creatine phosphokinase-MB and blood lipids.Results. The research showed positive correlation between the left ventricular ejection fraction and the heart rate variability and negative correlation between the rates of the rhythmic cardiogram and the sizes of the left heart chamber. There was also negative correlation between weak wall thickness of the left ventricular and interventricular septum and average weighted heart rate variability. The correlation analysis showed that higher rates of fibrinogen and creatine phosphokinase-MB changed the vegetative status.Сonclusions. The study showed that acute coronary pathology leads to a severe blockade regulation of vascular tone, an imbalance of the autonomic regulation of nA level. From the structural and functional parameters of the most pronounced impact on the dysregulation of the heart rate in patients with acute coronary syndrome has reduced pumping function (ejection fraction of the left ventricle) of the heart.