Validation of a score for predicting bleeding events during acute coronary syndromes

Abstract Background: Bleeding is a major complication in patients treated for acute coronary syndromes (ACS) with antithrombotic and invasive therapies. Consequently, the benefit of such therapies should be balanced against the potential risk of hemorrhagic complications. Therefore, a score to estimate individual risk of bleeding might represent an important tool in clinical decision-making.Objective: This study aims to create and validate a bleeding risk score for patients with ACS.Methods: Independent predictors of bleeding reported by the GRACE Registry were utilized. Variables with odds ratio (OR) ≥ 2.5 in that Registry added 3 points (previous history of bleeding), OR = 1.5-2.4 added 2 points (creatinine clearance 30, ST-deviation, peripheral artery disease and smoking). The score was validated in a cohort of 383 individuals with ACS. In-hospital bleeding was defined as hematocrit fall ≥ 10%, blood transfusion ≥ 2 units,