Clinical features and therapeutic changes of chronic pancreatitis （CP） ： 2180 cases

Objective To evaluate the clinical features of chronic pancreatitis （CP） patients admitted to Changhai Hospital in recent 20 years and some changes in treatment. Methods Data of 2180 CP patients admitted from 1995 to 2012 were retrospectively analyzed for the etiology, clinical symptoms, therapies and complication rates. Results Males to females ratio was 2. 24 ： 1, mean age 46.24 ± 15.99 years old. In terms of etiology, there were 740 cases of alcoholic CP （33.95%）, 1336 cases of idiopathic CP （61.28%）, 88 congenital pancreatic abnormalities （4. 04% ） and 16 hereditary CP （0. 73% ）. In the re- spect of complications, 535 patients （24. 54% ） were complicated with diabetes, 322 （ 14. 77% ） with steatorrhea and 108 （4. 95% ） with biliary strictures. In therapy, 1440 patients （66.06%） were treated by endoscopy, 490 patients underwent ESWL, and 468 patients （21.47%） accepted surgery. The radio of endoscopic therapy to surgical therapy increased from 0. 73 ： 1 in 2000 to 17. 6 ： 1 in 2012. The postoperative complication rates of endotherapy, ESWL and surgery were 4. 25%, 4. 18% and 3.42% respectively, which had no statistically significant difference （P 〉 0. 05）. Conclusion The mini-invasive endotherapy has partly replaced pancreatic surgery and become the first therapy for CP patients. Key words: Chronic pancreatitis;  Endotherapy;  Extracorporeal shock wave lithotripsy;  Surgery;  Clinical features;  Therapeutic mold