Пектин-зеиновые микросферы как носители лекарственных средств

The formation of microspheres from various pectin hydrogel complexes and corn zein in presence of calcium and zinc ions has been studied. It is shown that the formation of microspheres and their loading capacity for a drug (piroxicam) depend on the type of biopolymers, their ratio, sizes of bivalent ions, and the molecular mass of pectin. The complex formation between two biopolymers results predominantly from bivalent metal crosslinking and hydrophobic interaction. As a result, a series of microspheres have been prepared from biodegradable and biocompatible, naturally occurred materials, which are intended for controlled drug delivery system.