Gender and Age Differences in the Effectiveness of the Medifast 4 & 2 & 1 Meal Replacement (MR) Plan for Weight Loss in Overweight and Obese Adults: A Retrospective Chart Review of 21 Medifast Weight Control Centers

The 4 & 2 & 1 Plan is a calorie controlled meal plan (1000-1200 kcals/day) rich in high quality protein and includes MRs and regular foods. Body weight (wt) and body composition (BC) were collected at multiple times through 24 wks; the primary endpoint was wt change at 12 wks. Subgroup analyses by gender and age ( 3.5X after 12 wks in all subgroups. Loss of LM was similar (蠄5%) for all subgroups. Loss of FM was similar across age groups while males lost more FM than females. Controlling for baseline wt and time, male gen...