Application of direct on-line coupling of HPLC and SFC with 1HNMR spectroscopy for the investigation of monomeric acrylates

The separation of monomeric acrylates was performed with High Performance Liquid Chromatography (HPLC) and Supercritical Fluid Chromatography (SFC). A direct on-line structural assignment of all compounds by continuous-flow 1HNMR spectroscopy is possible with both separation techniques. The direct SFC-NMR coupling offers the advantage that the recorded continuous-flow 1HNMR spectrum is not obscured by solvent signals.