Dynamic changes of lysophosphatidic acid concentrations in cerebrospinal fluid of old patients with subarachnoid hemorrhage

Objective To investigate the relationship between dynamic changes of lysophosphatidic acid(LPA) concentration in cerebrospinal fluid(CSF) and cerebral vasospasm(CVS) in old patients with subarachnoid hemorrhage(SAH).Methods LPA levels in CSF were measured in 67 SAH patients from admission(within 24 hours from the bleeding) until day 28.The patients received daily transcranial Doppler study and neurological evaluation.On day 7,angiography was performed to verify the degree and extent of vasospasm.The patients were then divided into vasospasm group and no-vasospasm group.Results On day 7,LPA levels in CSF were significantly increased in the SAH group compared with the control group(P0.01).On day 14,LPA levels were also significantly different between groups,whereas on day 28,LPA levels were not significantly increased in both groups.On day 7,LPA levels in CSF of the CVS group were significantly increased compared with the no-CVS group(P0.01).On day 14,LPA levels were also significantly different between groups(P0.01).Conclusions LPA levels in CSF were markedly elevated during 7-14 days after SAH.The results suggest that there is a significant relationship between vasospasm and LPA levels in CSF.LPA levels in CSF parallel the CVS period and may be as a predictor of vasospasm.