Difficult-to-Treat Severe Asthma

Difficult-to-treat severe asthma constitutes approximately 5–10% of the asthmatic population, and continues to present a considerable therapeutic challenge. Use of the pragmatic definitions over the past 10 years has led to an improved delineation of these patients. This monograph gathers expertise in the paediatric and adult severe asthma fields. Giving rise to a comprehensive edition that summarises what has been achieved in understanding the different phenotypes, their biomarkers and the reasons and mechanisms that underlie difficult-to-treat severe asthma as well as the refractoriness to its current treatments. This volume also provides a physician's guide to the management of severe asthma with the optimal use of the currently available therapies, while pointing to the potential approaches we need to take in order to discover more effective treatments.