EP230 Solid papillary carcinoma of the breast: about two cases and literature review

Introduction/Background Solid papillary carcinoma (SPC) of the breast is a new histological entity described in the last WHO classification (2012). SPC is associated with invasive carcinoma in half of cases. 95% are unilateral. Methodology We reported two cases and reviewed publications using PubMed. Results Case1: A 73 year-old woman presented a history of adenoid carcinoma of the palate. She presented bilateral breast nodules. Clinically, we found a 25 mm nodule and a 10 mm condenstaion in the upper of the right and the left breast; respectively. There was no axillary lymph node. Breast imaging demonstrated a heterogeneous nodule of 22×10 mm in the right breast, classified as BIRADS 4 and a nodule of 10×5 mm in the left, classified as BIRADS 5. Needle biopsies confirmed bilateral invasive ductal carcinoma. She conducted lympectomies. Histologically, it showed a SPC of 9 mm in the left breast. In the right side, 2 separate foci was shown; a SPC of 12 mm and an intra ductal carcinoma of 22 mm. She refused any complementary treatment Case2: A 48 year-old woman presented with a mass of the left breast. Clinically, we noticed a hard and movable nodule of 20 mm in the lower outer quadrant of the left breast. There were no lymph nodes. The breast imaging showed an ill-circumscribed mass of 17 mm, classified as BI-RADS 5. Needle biopsy concluded to an invasive ductal carcinoma. She undertook a left lympectomy and sentinel lymph node. The frozen examination showed a 17 mm invasive ductal carcinoma with negative shaved margins and negative axillary nodes. Histologically, it corresponds to a SPC of 17 mm. She will receive radiotherapy Conclusion Solid papillary carcinoma is a low grade neoplasm occurring in elder women. When solid papillary carcinoma is associated with invasive carcinoma prognosis is poorer. The management of this disease still not well established. The management still not well established. Disclosure Nothing to disclose.